I have the same kind of problem occuring on several computers. I haven't found any common nominator, but sometimes PDFCreator loses all the self made profiles and also changes the language. It almost seems like PDFCreator restores the default settings. This is a big problem because it activates the "Show progress during conversion" and "Open document" tabs which seem to cause sluggishness and overall instability. This seems to be happening with the 2.4.1 version but I didn't notice this kind of behavior with the previous version. Any ideas how I could make the settings stick?