I think I am having the same issue here. When a user on my terminal server trys to print to PDFCreator they get an error. If I look at their PDFCreator options their temp directory is defaulting to another user's profile, not their own profile. Why is this? Is there a fix for this issue? I am running Server 2008.
Did you put the Terminal Server in Install Mode before installing pdfcreator ? i.e. did you logoff all users and ran "change user /install" before running setup.exe and "change user /execute" after ?